Pool was born in Soglio, Switzerland and raised there, in Lausanne. Her father was Jewish, and was a Holocaust survivor from Poland. Her mother's family was Christian and Swiss.

Her film À corps perdu (1988) was selected for official competition in the Venice Film Festival and her film Mouvements du désir (1994) was screened at the Sundance Film Festival. She has been nominated 3 times for the Genie Award for Best Achievement in Direction for her films La Femme de l'hôtel (1984), Mouvements du désir (1994), and Emporte-moi (1999).

In 2006 she was awarded the Prix Albert-Tessier. In 2011, Pool completed the National Film Board of Canada documentary film Pink Ribbons, Inc., partly based on the 2006 book Pink Ribbons, Inc: Breast Cancer and the Politics of Philanthropy, which is premiering at the 2011 Toronto International Film Festival.